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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > MG-132CAS：133407-82-6
Molecular Formula：C26H41N3O5
Molecular Weight：475.62
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 133407-82-6 |
| Name | MG-132 |
| Molecular Formula | C26H41N3O5 |
| Molecular Weight | 475.62 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00674886 |
| SMILES | O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C([H])=O)CC(C)C)=O)=O)CC(C)C |
| InChIKey | TZYWCYJVHRLUCT-VABKMULXSA-N |
| InChI | InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1 |
| PubChem CID | 462382 |
| Target Point | Proteasome;Autophagy |
| Passage | Autophagy;Metabolic Enzyme&Protease |
| Background | MG-132 is a novel, specific, potent, reversible and cell-permeable proteasome inhibitor, and also inhibits calpain. It is also a polypeptide aldehyde, a potent autophagy activator. |
| Biological Activity | MG-132是一种有效, 可逆, 能渗透细胞的 20S蛋白酶体抑制剂。它抑制蛋白酶体胰凝乳蛋白酶样肽酶活性的 IC50值为 24.2 nM[1]。 |
| IC50 | IC50: 24.2nM (chymotrypsin-like activity) [1] |
| Data Literature Source | [1]. Braun HA， et al. Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines. J Biol Chem. 2005 Aug 5; 280 (31) :28394-401. [2]. Han YH， et al. The effect of MG132， a proteasome inhibitor on HeLa cells in relation to cell growth， reactive oxygen species and GSH. Oncol Rep. 2009 Jul; 22 (1) :215-21. [3]. Fan WH， et al. Proteasome inhibitor MG-132 induces C6 glioma cell apoptosis via oxidative stress. Acta Pharmacol Sin. 2011 May; 32 (5) :619-25. [4]. Matsumoto Y， et al. Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating theproteasome inhibitor MG132. Cancer Sci. 2016 Jun; 107 (6) :773-81. [5]. Chen B， et al. MG132， a proteasome inhibitor， attenuates pressure-overload-induced cardiac hypertrophy in rats by modulation of mitogen-activated protein kinase signals. Acta Biochim Biophys Sin (Shanghai) . 2010 Apr; 42 (4) :253-8. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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