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My Cart> Biochemical Reagents > Other Biochemical Reagents > Phorbol 12-Myristate 13-AcetateCAS：16561-29-8
Molecular Formula：C36H56O8
Molecular Weight：616.8
Appearance：Crystalline solid
Storage：Store at -20℃，avoid light，2 years.
Purity：≥98%
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| Name | Phorbol 12-myristate 13-acetate |
| CAS | 16561-29-8 |
| Molecular Formula | C36H56O8 |
| Molecular Weight | 616.8 |
| Storage | Store at -20℃，avoid light，2 years. |
| Appearance | Crystalline solid |
| Purity | ≥98% |
| Source | Penicillium |
| Solubility | 10mg/mL in DMSO |
| Unit | Bottle |
| Specification | 1mg 5mg |
PMA (synonymous name: TPA) is a phorbol ester PKC activator widely used in vitro and in vivo. PMA binds PKC(Ki =2.6 nM) and activates its function, showing an extremely broad inhibition spectrum in both cells and tissues. PMA could inhibit Fas-induced apoptosis, but could also induce apoptosis in HL-60 cells. PMA is a highly effective tumor promoter and can promote skin tumor formation in mice. Although PMA is highly toxic, it still shows anti-leukemia and anti-neutropenia activities in humans.
Use concentration:
The specific concentration of PMA should be referred to the relevant literature, and explored and optimized according to the experimental conditions (such as experimental purpose, cell type, culture characteristics, etc.).
Preparation and storage:
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 100mM.
This product may not be suitable for inducing the differentiation of THP-1 cells into macrophages.
Note: PMA can be dissolved in DMSO, and the solution dissolved in DMSO is used as storage solution. The solution diluted with water reagent can not be stored at -20 degrees and is protected from light. It is recommended to use current dilution.
Note：Product information may be optimized and upgraded. Please refer to the actual label information for accuracy.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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为啥这个不能用于诱导THP-1细胞分化，是证实了吗？它和货号IP1010的有啥区别？ 2023-05-27 21:13:39
Administrator您好，诱导细胞分化建议使用IP1010，IP1010这个纯度等级更高。
用DMSO稀释后的可以在-20保存多久啊 2022-08-17 22:40:41
Administrator-20℃保存建议在一个月内使用，此外试剂存储还要注意避光，试剂对光也是有一定的敏感性的。
请问可以存放在负80吗 2022-07-05 10:30:03
Administrator可以-80℃保存