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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > AldosteroneCAS：52-39-1
Molecular Formula：C21H28O5
Molecular Weight：360.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥97%
Appearance：White to off-white Solid
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| CAS | 52-39-1 |
| Name | Aldosterone |
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥97% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-139-9 |
| MDL | MFCD00051136 |
| SMILES | O=C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O |
| InChIKey | PQSUYGKTWSAVDQ-ZVIOFETBSA-N |
| InChI | InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1 |
| PubChem CID | 5839 |
| Target Point | Mineralocorticoid Receptor |
| Passage | Endocrinology & Hormones |
| Background | Aldosterone is a steroid hormone synthesized and secreted by the glomerular zone (ZG) of the adrenal cortex in response to activation of the renin-angiotensin system (RAS) or a high potassium diet. |
| Biological Activity | Aldosterone 是原发性盐皮质激素。Aldosterone 是一种类固醇激素，通过肾上腺皮质的肾小球区 (ZG) 对肾素-血管紧张素系统激活 (RAS) 或高钾饮食反应而合成和分泌。Aldosterone 活性在细胞水平上依赖于胞浆/核盐皮质激素受体 (MR) 的结合和激活。[1-5] |
| Data Literature Source | [1]. Nanba K，et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223. [2]. Cannavo A，et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598. [3]. Ikeda U，et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73. [4]. Martín-Fernández B，et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104. [5]. Dinh QN，et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153. |
| Unit | Piece |
| Specification | 1mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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