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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > AcetazolamideCAS：59-66-5
Molecular Formula：C4H6N4O3S2
Molecular Weight：222.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 59-66-5 |
| Name | Acetazolamide |
| Molecular Formula | C4H6N4O3S2 |
| Molecular Weight | 222.25 |
| Solubility | Soluble in DMSO ≥50mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-440-5 |
| MDL | MFCD00003105 |
| SMILES | CC(NC1=NN=C(S(=O)(N)=O)S1)=O |
| InChIKey | BZKPWHYZMXOIDC-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) |
| PubChem CID | 1986 |
| Target Point | Carbonic Anhydrase |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a carbonic anhydrase inhibitor. |
| Biological Activity | Acetazolamide 是一种碳酸酐酶 (carbonic anhydrase, CA) IX 抑制剂[1]。 |
| IC50 | IC50 : 30nM( hCA IX) [1] |
| Data Literature Source | [1]. Hou Z， et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26; 132:1-10. [2]. Gao H， et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun; 15 (6) :9299-9306. [3]. Bayat Mokhtari R， et al. Acetazolamide potentiates the anti-tumor potential of HDACi， MS-275， in neuroblastoma. BMC Cancer. 2017 Feb 24; 17 (1) :156. [4]. Kassamali R， et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec; 19 (6) :276-8. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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