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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > AG-490CAS：133550-30-8
Molecular Formula：C17H14N2O3
Molecular Weight：294.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 133550-30-8 |
| Name | AG-490 |
| Molecular Formula | C17H14N2O3 |
| Molecular Weight | 294.3 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00236452 |
| SMILES | O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2.[(E)] |
| InChIKey | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| InChI | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| PubChem CID | 5328779 |
| Target Point | EGFR;STAT3;JAK2/3 |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | AG-490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. |
| Biological Activity | AG-490是酪氨酸激酶抑制剂，其抑制EGFR，Stat-3 和 JAK2/3。[1-4] |
| Data Literature Source | [1]. Dowlati A， et al. Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy. Mol Cancer Ther. 2004 Apr; 3 (4) :459-63 [2]. Wang LH， et al. JAK3， STAT， and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation ofIL-2-mediated T cell response. J Immunol. 1999 Apr 1; 162 (7) :3897-904. [3]. Davoodi-Semiromi A， et al. The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice. PLoS One. 2012; 7 (5) :e36079. [4]. Cheppudira BP， et al. Anti-hyperalgesic effects of AG490， a Janus kinase inhibitor， in a rat model of inflammatory pain. Biomed Rep. 2015 Sep; 3 (5) :703-706. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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