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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > 1-Naphthyl PP1 HydrochlorideCAS：956025-47-1
Molecular Formula：C19H19N5·HCl
Molecular Weight：353.85
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 956025-47-1 |
| Name | 1-Naphthyl PP1 Hydrochloride |
| Molecular Formula | C19H19N5·HCl |
| Molecular Weight | 353.85 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| MDL | MFCD28142637 |
| SMILES | CC(N1N=C(C2=C3C=CC=CC3=CC=C2)C4=C(N)N=CN=C41)(C)C.[H]Cl |
| InChIKey | UKLRSYUALPIALU-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H19N5.ClH/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14;/h4-11H,1-3H3,(H2,20,21,22);1H |
| PubChem CID | 10066681 |
| Target Point | Bcr-Abl;Src;CDK2;CAMK II;c-Fyn |
| Passage | Cell Cycle;Neuronal Signaling;Protein Tyrosine Kinase/RTK |
| Background | 1-Naphthyl PP1 (hydrochloride) 1-tert-butyl-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride is a selective src family Kinase inhibitor capable of inhibiting v-Src and c-Fyn, c-Abl, CDK2 and CAMK II. |
| Biological Activity | 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn， c-Abl， CDK2 and CAMK II with IC50s of 1.0， 0.6， 0.6， 18 and 22 μM， respectively[1]. |
| Data Literature Source | [1]. Tandon M，et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8(9):e75601. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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