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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > ACY-738CAS：1375465-91-0
Molecular Formula：C14H14N4O2
Molecular Weight：270.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1375465-91-0 |
| Name | ACY-738 |
| Molecular Formula | C14H14N4O2 |
| Molecular Weight | 270.29 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28347706 |
| SMILES | O=C(NO)C(C=N1)=CN=C1NC2(CC2)C3=CC=CC=C3 |
| InChIKey | LIIWIMDSZVNYHY-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17) |
| PubChem CID | 57381425 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | ACY-738 N-hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide is an HDAC inhibitor. |
| Biological Activity | ACY-738以低纳摩尔浓度抑制HDAC6，IC50为1.7 nM。其对HDAC6的选择性比对其他I类HDACs高60-1500倍。[1-2] |
| Data Literature Source | [1] Jochems J，et al. Neuropsychopharmacology. 2014，39(2):389-400. [2] Regna NL，et al. Clin Immunol. 2016，162:58-73. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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