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IC261

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Cat.No：II0280 Solarbio

CAS：186611-52-9

Molecular Formula：C₁₈H₁₇NO₄

Molecular Weight：311.33

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow Solid

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Product Information

CAS	186611-52-9
Name	IC261
Molecular Formula	C₁₈H₁₇NO₄
Molecular Weight	311.33
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00118156
SMILES	O=C1NC2=C(C=CC=C2)/C1=C\C3=C(OC)C=C(OC)C=C3OC
InChIKey	JBJYTZXCZDNOJW-JLHYYAGUSA-N
InChI	InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+
PubChem CID	5288600
Target Point	Casein Kinase（CK）
Passage	Cell Cycle;DNA Damage/DNA Repair; Stem Cells
Background	Ibuprofen is a COX-1 and COX-2 inhibitor with anti-inflammatory activity.
Biological Activity	IC261 is a selective， ATP-competitive CK1 inhibitor， with IC50s of 1 μM， 1 μM， 16 μM for Ckiδ， Ckiε and Ckiα1， respectively.[1-3]
Data Literature Source	[1]. Mashhoon N， et al. Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60. [2]. St?ter M， et al. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene. 2005 Dec 1;24(54):7964-75. [3]. Brockschmidt C， et al. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut. 2008 Jun;57(6):799-806.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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