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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > LY294002CAS：154447-36-6
Molecular Formula：C19H17NO3
Molecular Weight：307.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to brown Solid
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| CAS | 154447-36-6 |
| Name | LY294002 |
| Molecular Formula | C19H17NO3 |
| Molecular Weight | 307.34 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1312995-182-4 |
| MDL | MFCD00270881 |
| SMILES | O=C1C=C(OC2=C1C=CC=C2C3=CC=CC=C3)N4CCOCC4 |
| InChIKey | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 |
| PubChem CID | 3973 |
| Target Point | PI3K;CK2;DNA-PK |
| Passage | PI3K/Akt/mTOR;Cell Cycle;DNA Damage/DNA Repair; Stem Cells; |
| Background | LY294002 is a broad-spectrum PI3K inhibitor that also inhibits CK2 activity. LY294002 is also a competitive DNA-PK inhibitor. |
| Biological Activity | LY294002 是一种广谱 PI3K 抑制剂，抑制 PI3Kα, PI3Kδ 和 PI3Kβ的 IC50 分别为 0.5, 0.57, 0.97 μM。 它也可抑制 CK2的活性，IC50 为 98 nM。[1-5] |
| IC50 | p110α:0.5μM;p110δ:0.57μM;p110β:0.97μM [1-5] |
| Data Literature Source | [1]. Chaussade C，et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404(3):449-58. [2]. Gharbi SI，et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404(1):15-21. [3]. Jiang H，et al. Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma invitro and in vivo. J Exp Clin Cancer Res. 2010 Apr 22;29:34. [4]. Ueda K，et al. Differential effects of LY294002 and wortmannin on neurons and vascular endothelial cells in the rat retina. Pharmacol Rep. 2013;65(4):854-62. [5]. Wang X，et al. Remote Ischemic Postconditioning Protects against Myocardial Ischemia-Reperfusion Injury by Inhibition of the RAGE-HMGB1 Pathway. Biomed Res Int. 2018 Jan 23;2018:4565630. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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