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Acalabrutinib

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Cat.No：IA0780 Solarbio

CAS：1420477-60-6

Molecular Formula：C₂₆H₂₃N₇O₂

Molecular Weight：465.51

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1420477-60-6
Name	Acalabrutinib
Molecular Formula	C₂₆H₂₃N₇O₂
Molecular Weight	465.51
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 814-272-0
MDL	MFCD29472294
SMILES	O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
InChIKey	WDENQIQQYWYTPO-IBGZPJMESA-N
InChI	InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
PubChem CID	71226662
Target Point	Btk
Passage	Protein Tyrosine Kinase/RTK;Angiogenesis
Background	It is a selective second-generation BTK inhibitor with good target specificity.
Biological Activity	Acalabrutinib (ACP-196) 是选择性的第二代BTK抑制剂，抑制B细胞表面原抗体信号通路的激活，IC50为3 nM。它具有很好的靶标特异性，对BTK的选择性比对其他TEC激酶家族成员如ITK、TXK、BMK和TEC的选择性高323-, 94-, 19-, 9-倍。对EGFR没有活性。[1-3]
Data Literature Source	[1] Wu J，et al. J Hematol Oncol. 2016，9:21. [2] Heather L. Gardner，et al .Cancer Res. 2014，74(19 Supplement):1744. [3] Todd Covey，et al. Cancer Res. 2015，75 (15 Supplement):2596.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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