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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > L-NAME HydrochlorideCAS：51298-62-5
Molecular Formula：C7H15N5O4·HCl
Molecular Weight：269.69
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 51298-62-5 |
| Name | L-NAME Hydrochloride |
| Molecular Formula | C7H15N5O4·HCl |
| Molecular Weight | 269.69 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 257-116-1 |
| MDL | MFCD00039052 |
| SMILES | N[C@@H](CCCNC(N[N+]([O-])=O)=N)C(OC)=O.[H]Cl |
| InChIKey | QBNXAGZYLSRPJK-JEDNCBNOSA-N |
| InChI | InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1 |
| PubChem CID | 135193 |
| Target Point | NO Synthase |
| Passage | Immunology & Inflammation |
| Background | L-NAME hydrochloride is an inhibitor of NOS. |
| Biological Activity | L-NAME hydrochloride是 NOS 的抑制剂，IC50 为70 μM。[1-5] |
| Data Literature Source | [1]. Pfeiffer S，et al. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement forbioactivation to the free acid，NG-nitro-L-arginine. Br J Pharmacol. 1996 Jul;118(6):1433-40. [2]. Kopincová J，et al. L-NAME in the cardiovascular system - nitric oxide synthase activator Pharmacol Rep. 2012;64(3):511-20. [3]. Lo HC，et al. The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis. PLoSOne. 2016 Mar 23;11(3):e0151973. [4]. Luo H，et al. Effect of nitric oxide synthase inhibitor L-NAME on fear extinction in rats: a task-dependent effect. Neurosci Lett. 2014 Jun 20;572:13-8. [5]. Ocsan RJ，et al. Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. J Physiol Pharmacol. 2013 Dec;64(6):727-36. |
| Unit | Bottle |
| Specification | 200mg 10mM*1mL in Water 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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