Cytisine
Cat.No:IC0940 Solarbio
CAS:485-35-8
Molecular Formula:C11H14N2O
Molecular Weight:190.24
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:HPLC≥98%
Appearance:White to off-white Solid
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Small Molecule Compounds >
Inhibitors & Antagonists & Agonists >
Neuronal Signal Pathway >
CytisineCAS:485-35-8
Molecular Formula:C11H14N2O
Molecular Weight:190.24
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:HPLC≥98%
Appearance:White to off-white Solid
Qty:
Size:
CAS | 485-35-8 |
Name | Cytisine |
Molecular Formula | C11H14N2O |
Molecular Weight | 190.24 |
Solubility | Soluble in Water/DMSO |
Purity | HPLC≥98% |
Appearance | White to off-white Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC | EINECS 207-616-0 |
MDL | MFCD00136048 |
SMILES | O=C1N(C[C@@]2([H])C[C@]3([H])CNC2)C3=CC=C1 |
InChIKey | ANJTVLIZGCUXLD-DTWKUNHWSA-N |
InChI | InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1 |
PubChem CID | 10235 |
Target Point | nAChR |
Passage | Neuronal Signaling;Membrane Transporter&Ion Channel |
Background | Cytisine is an alkaloid that is a partial agonist of the α4β2 nicotinic acetylcholinergic receptors (α4β2 nAChRs) and a partial complete agonist that includes both β4 and α7 receptors. |
Biological Activity | Cytisine 是一种生物碱,可在 Laburnum 和 Cytisus 等中提取得到。 Cytisine 是 α4β2 nAChRs的部分激动剂[1],也是包含 β4 受体和 α7 受体的偏完全性激动剂[2]。 |
Data Literature Source | [1]. Pabreza LA,et al. [3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol. 1991 Jan;39(1):9-12. [2]. Grebenstein PE,et al. The effects of noncontingent and self-administered cytisine on body weight and meal patterns in male Sprague-Dawley rats. Pharmacol Biochem Behav. 2013 Sep;110:192-200. [3]. Yu L,et al. Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells. Oncol Rep. 2018 Mar;39(3):1475-1484 |
Unit | Bottle |
Specification | 20mg 10mM*1mL in DMSO 50mg |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Note:
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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