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My Cart> Antibodies > Loading Control Antibodies > Nucleus > Anti-Cleaved PARP Monoclonal AntibodyReactivity：Human
Application：WB,IHC
Clone Type：Monoclonal Antibody
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Gene ID：142
Host：Mouse
Qty：
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| Name | Anti-Cleaved PARP Monoclonal Antibody |
| Host | Mouse |
| Clone Type | Monoclonal Antibody |
| Subtype | IgG1 |
| Clone Number | Mix |
| Dilution Ratio | WB 1:2000-5000. IHC 1:200-500. |
| Target | Cleaved PARP |
| Background | Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. |
| Swiss Prot | P09874 |
| Gene ID | 142 |
| Subcellular Location | Nucleus nucleolus |
| Immunogen | Synthetic Peptide |
| Calculated MW | 116/89kDa |
| Purification Method | Saturated ammonium sulfate precipitation |
| Storage Buffer | PBS with 0.02% sodium azide，50% glycerol，pH7.3. |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Unit | Piece |
| Specification | 50ul 100ul |
| Reactivity | Human |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with Cleaved PARP antibody diluted at 1:2000 ,lane: Jurkat
Immunohistochemistry of paraffin-embedded Human Tonsil Tissue with Cleaved PARP antibody diluted at 1:500
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