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My CartReactivity：Mouse,Rat,Human
Application：IHC,WB
Clone Type：Monoclonal Antibody
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Gene ID：6774
Host：Mouse
Qty：
Size：
| Name | Anti-STAT3 Monoclonal Antibody |
| Host | Mouse |
| Clone Type | Monoclonal Antibody |
| Subtype | IgG1 |
| Clone Number | 3F4 |
| Dilution Ratio | WB 1:1000-2000. IHC 1:100-200. |
| Target | STAT3 |
| Background | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation . Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. |
| Swiss Prot | P40763 |
| Gene ID | 6774 |
| Subcellular Location | Cytoplasm Nucleus |
| Immunogen | Recombinant Protein |
| Calculated MW | 83/88kDa |
| Purification Method | Saturated ammonium sulfate precipitation |
| Storage Buffer | PBS with 0.02% sodium azide，50% glycerol，pH7.3. |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Unit | Piece |
| Specification | 50ul 100ul |
| Reactivity | Mouse Rat Human |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with STAT3 antibody diluted at 1:2000 , lane1-3: Rat Heart Tissue, Mouse Heart Tissue, Hela
Immunohistochemistry of paraffin-embedded Human Colon cancer with STAT3 antibody diluted at 1:200
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