| English Name |
Anti-MMP2 Monoclonal Antibody |
| Host |
Mouse |
| Clone Type |
Monoclonal Antibody |
| Subtype |
IgG1 |
| Clone Number |
3A8-C1-E8 |
| Dilution Ratio |
WB 1:500-1000. IF 1:50-200. ICC 1:50-200. |
| Target |
MMP2 |
| Synonyms |
MMP-2, 72 kDa gelatinase, 72kD type IV collagenase, CLG 4, CLG 4A, CLG4, CLG4A, Collagenase Type 4 alpha, Collagenase type IV A, Gelatinase A, Gelatinase alpha, Gelatinase neutrophil, Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase, Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), Matrix Metalloproteinase 2, Matrix metalloproteinase II, MMP 2, MMP II, MONA, Neutrophil gelatinase, TBE 1, MMP2_HUMAN |
| Background |
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Swiss Prot |
P08253 |
| Gene ID |
4313 |
| Subcellular Location |
Cytoplasm Membrane Mitochondrion Nucleus Secreted extracellular matrix extracellular space |
| Immunogen |
Recombinant protein of human MMP2 |
| Calculated MW |
74kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 0.02% sodium azide，0.5% BSA，50% glycerol，pH7.3. |
| Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
| Piece |
Piece |
| Specification |
100ul 50ul |
| Reactivity |
Mouse Human |
| Application |
ICC IF WB |
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