| English Name |
Anti-ATF6 Polyclonal Antibody |
| Chinese Name |
活化转录因子6抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Dilution Ratio |
WB 1:500-1000. IF 1:50-200. IHC 1:50-200. |
| Target |
ATF6 |
| Synonyms |
Activating transcription factor 6 alpha, Activating transcription factor 6, ATF 6, ATF6 alpha, ATF6, ATF6-alpha, ATF6A, ATF6A_HUMAN, cAMP dependent transcription factor ATF 6 alpha, cAMP-dependent transcription factor ATF-6 alpha, Cyclic AMP dependent transcription factor ATF 6 alpha, DKFZp686P2194, ESTM49, FLJ21663, Processed cyclic AMP dependent transcription factor ATF 6 alpha, Processed cyclic AMP-dependent transcription factor ATF-6 alpha |
| Background |
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. |
| Swiss Prot |
P18850 |
| Gene ID |
22926 |
| Subcellular Location |
Endoplasmic reticulum membrane Nucleus Single-pass type II membrane protein |
| Immunogen |
Recombinant protein of human ATF6 |
| Public Immunogen Range |
190-300aa |
| Calculated MW |
75kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 0.02% sodium azide，50% glycerol，pH7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Specification |
100ul 50ul |
| Reactivity |
Rat Mouse Human |
| Application |
IF IHC WB |
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