English Name |
Anti-CD40 Polyclonal Antibody |
Chinese Name |
肿瘤坏死因子受体超家族成员5抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:500-1000. IHC 1:50-200. IF 1:50-200. |
Target |
CD40 |
Synonyms |
Tumor necrosis factor receptor superfamily , member 5,B cell associated molecule CD40,B cell surface antigen CD40,B cell-associated molecule,B-cell surface antigen CD40,Bp50,CD 40,CD40,CD40 antigen (TNF receptor superfamily member 5),CD40 antigen,CD40 molecule,CD40 molecule, TNF receptor superfamily member 5,CD40 protein,CD40 type II isoform |
Background |
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Swiss Prot |
P25942 |
Gene ID |
958 |
Subcellular Location |
Cell membrane Secreted Single-pass type I membrane protein |
Immunogen |
Recombinant Protein of human CD40 |
Public Immunogen Range |
198-277aa |
Calculated MW |
31kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
100ul 50ul |
Reactivity |
Mouse Human |
Application |
IF IHC WB |