English Name |
Anti-ABL1 Polyclonal Antibody |
Chinese Name |
非受体酪氨酸激酶c-Abl抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:100-500. IHC 1:50-200. IF 1:50-200. |
Target |
ABL1 |
Synonyms |
Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine protein kinase 1,Abl 1,ABL,ABL proto oncogene 1 non receptor tyrosine kinase,ABL1,ABL1_HUMAN,bcr/abl,bcr/c abl oncogene protein,c ABL,c abl oncogene 1 non receptor tyrosine kinase,c abl oncogene 1 receptor tyrosine kinase,c ABL1,JTK7,p150,Proto oncogene tyrosine protein kinase ABL1,Proto-oncogene c-Abl |
Background |
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. |
Swiss Prot |
P00519 |
Gene ID |
25 |
Subcellular Location |
Cytoplasm Lipid-anchor Mitochondrion Nucleus Nucleus membrane cytoskeleton |
Immunogen |
Recombinant protein of human ABL1 |
Public Immunogen Range |
1000-1130aa |
Calculated MW |
123kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
100ul 50ul |
Reactivity |
Human Mouse Rat |
Application |
IF IHC WB |