| English Name |
Anti-INCENP Polyclonal Antibody |
| Chinese Name |
内着丝粒蛋白抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Dilution Ratio |
WB 1:500-2000. |
| Target |
INCENP |
| Synonyms |
binds and activates aurora B and C in vivo and in vitro, Chromosomal passenger protein, FLJ31633, INCE_HUMAN, INCENP, Inner centromere protein, Inner centromere protein antigens 135/155kDa, Inner centromere protein antigens 135kD 155kD, Inner centromere protein INCENP, MGC111393 |
| Background |
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]). |
| Swiss Prot |
Q9NQS7 |
| Gene ID |
3619 |
| Subcellular Location |
Chromosome Cytoplasm Nucleus centromere cytoskeleton kinetochore spindle |
| Immunogen |
Recombinant protein of human INCENP |
| Public Immunogen Range |
785-914aa |
| Calculated MW |
105kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 0.02% sodium azide，50% glycerol，pH7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Rat Human |
| Application |
WB |
English
中文
Manual Download
