| English Name |
Anti-SKP2 Polyclonal Antibody |
| Chinese Name |
S期激酶相关蛋白2(p45)抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Dilution Ratio |
WB 1:500-2000. |
| Target |
SKP2 |
| Synonyms |
p45skp2, skp2p45, p45, skp2 p45,S-phase kinase-associated protein 2, SKP2, CDK2/Cyclin A associated protein p45, Cyclin A/CDK2 associated protein p45, F box protein Skp2, F box/LRR repeat protein 1, FBL 1, FBL1, FBXL 1, FBXL1, FLB 1, FLB1, MGC1366, SKP2_HUMAN |
| Background |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. |
| Swiss Prot |
Q13309 |
| Gene ID |
6502 |
| Subcellular Location |
Cytoplasm Nucleus |
| Immunogen |
A synthetic peptide of human SKP2 |
| Public Immunogen Range |
1-100aa |
| Calculated MW |
48kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 0.02% sodium azide，50% glycerol，pH7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Y-Dilution Ratio |
"WB 1:500-2000. IF 1:50-200." |
| Specification |
50ul 100ul |
| Reactivity |
Rat Mouse Human |
| Application |
IF WB |
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