English Name |
Anti-ABCC2 Polyclonal Antibody |
Chinese Name |
多药耐药相关蛋白2抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:500-1000. IF 1:50-200. |
Target |
ABCC2 |
Synonyms |
multidrug resistance-associated protein2, ABC30, ABCC2, ATP binding cassette sub family C (CFTR/MRP) member 2, ATP binding cassette subfamily C member 2, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, CMOAT, CMOAT1, cMRP, DJS, KIAA1010, MRP 2, MRP-2, MRP2, Multidrug resistance associated protein 2, MRP2_HUMAN, ATP-binding cassette sub-family C member 2, Multidrug resistance-associated protein 2 |
Background |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. |
Swiss Prot |
Q92887 |
Gene ID |
1244 |
Subcellular Location |
Apical cell membrane Multi-pass membrane protein |
Immunogen |
Recombinant protein of human ABCC2 |
Public Immunogen Range |
180-315aa |
Calculated MW |
174kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Rat Mouse Human |
Application |
IF WB |