English Name |
Anti-IMPA1 Polyclonal Antibody |
Chinese Name |
肌醇-1-单磷酸酶1抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:500-2000. IHC 1:25-100. |
Target |
IMPA1 |
Synonyms |
IMP 1, IMP, IMPA 1, IMPA, IMPA1, IMPA1_HUMAN, IMPase 1, IMPase, Inositol 1(or 4) monophosphatase, Inositol monophosphatase 1, Inositol monophosphatase, Inositol(myo) 1(or 4) monophosphatase 1, Inositol-1(or 4)-monophosphatase 1, Lithium sensitive myo inositol monophosphatase A1, Lithium-sensitive myo-inositol monophosphatase A1 |
Background |
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. |
Swiss Prot |
P29218 |
Gene ID |
3612 |
Subcellular Location |
Cytoplasm Nucleus |
Immunogen |
Recombinant protein of human IMPA1 |
Calculated MW |
30kDa |
Purification Method |
Affinity purification |
Storage Buffer |
pH7.4 PBS,0.05% NaN3,40% Glycerol. |
Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Mouse Rat Human |
Application |
IHC WB |