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Erastin

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Cat.No：IE0310 Solarbio

CAS：571203-78-6

Molecular Formula：C₃₀H₃₁ClN₄O₄

Molecular Weight：547.04

Storage：Powder:2-8℃，2 years

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	571203-78-6
Name	Erastin
Molecular Formula	C₃₀H₃₁ClN₄O₄
Molecular Weight	547.04
Solubility	Soluble in DMSO ≥10mg/mL;Soluble in Water ＜1mg/mL(This product is not stable in solution, it is recommended that you use it now)
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years
MDL	MFCD09837984
SMILES	O=C1N(C2=CC=CC=C2OCC)C(C(N3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)C)=NC5=C1C=CC=C5
InChIKey	BKQFRNYHFIQEKN-UHFFFAOYSA-N
InChI	InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
PubChem CID	11214940
Target Point	Ferroptosis
Passage	Apoptosis
Background	Erastin is an activator of iron-induced cell death (ferroptosis).
Biological Activity	Erastin是Ferroptosis激活剂[1-3]。
Data Literature Source	[1]. Dixon SJ，et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72. [2]. Xie Y，et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79. [3]. Huo H，et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605.
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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