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My CartCAS：89464-63-1
Molecular Formula：C6H9NO5
Molecular Weight：175.14
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
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| CAS | 89464-63-1 |
| Name | DMOG |
| Molecular Formula | C6H9NO5 |
| Molecular Weight | 175.14 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD05865098 |
| SMILES | O=C(OC)CNC(C(OC)=O)=O |
| InChIKey | BNJOZDZCRHCODO-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9) |
| PubChem CID | 560326 |
| Target Point | HIF/HIF Prolyl-Hydroxylase |
| Passage | HIF |
| Background | DMOG is a competitive HIF-1α prolyl hydroxylase (HIF-PH) inhibitor. |
| Biological Activity | DMOG是可渗透细胞，竞争型的 HIF-1α脯氨酰羟化酶 (HIF-PH) 抑制剂[1]。 |
| Data Literature Source | [1]. Baader E，et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro，in isolated microsomes and in embryonic chicken tissues. Biochem J. 1994 Jun 1;300 (Pt 2):525-30. [2]. Milkiewicz M，et al. Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. J Physiol. 2004 Oct 1;560(Pt 1):21-6. [3]. Schultz K，et al. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L921-7. [4]. Li X，et al. Up-regulation of hypoxia-inducible factor-1α enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):112-8. |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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