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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > AstilbinCAS：29838-67-3
Molecular Formula：C21H22O11
Molecular Weight：450.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 29838-67-3 |
| Name | Astilbin |
| Molecular Formula | C21H22O11 |
| Molecular Weight | 450.39 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 694-695-3 |
| MDL | MFCD20274680 |
| SMILES | O=C1[C@@H]([C@@H](C2=CC(O)=C(O)C=C2)OC3=CC(O)=CC(O)=C13)O[C@@](O[C@@H](C)[C@H](O)[C@H]4O)([H])[C@@H]4O |
| InChIKey | ZROGCCBNZBKLEL-MPRHSVQHSA-N |
| InChI | InChI=1S/C21H22O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-26,28-29H,1H3/t7-,15-,17+,18+,19+,20-,21-/m0/s1 |
| PubChem CID | 119258 |
| Target Point | Keap1-Nrf2 |
| Passage | NF-κB |
| Background | Astilbin is a flavonoid that enhances NRF2 activation and inhibits TNF-α expression and NF-κB activation. |
| Biological Activity | Astilbin 是一种黄酮类化合物，可从 Smilax glabra 根茎中分离。Astilbin 增强 NRF2 活化。Astilbin 还抑制 TNF-α 表达和 NF-κB 活化。[1] |
| Data Literature Source | [1]. Wang SW，et al. Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food Chem Toxicol. 2018 Apr;114:227-236 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Gegentana, et al. J Ethnopharmacol. 2020 Aug 10;258:112886.
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Topical astilbin ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice via suppression dendritic cell-Th17 inflammation axis
Click to check >>Author：Xu Q; Liu Z; Cao Z; Shi Y; Yang N; Cao G; Zhang C;
IF：5.3000
Publish_to：J Cell Mol Med
PMID：35023281
Discovery of the active compounds of Smilacis Glabrae Rhizoma by utilizing the relationship between the individual differences in blood drug concentration and the pharmacological effect in rats
Click to check >>Author：Gegentana;XuF;LiFC;ZhangYF;ShenSJ;YangP;YangXX;Sha
IF：4.2750
Publish_to：J Ethnopharmacol
PMID：32325179
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