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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > AcacetinCAS：480-44-4
Molecular Formula：C16H12O5
Molecular Weight：284.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 480-44-4 |
| Name | Acacetin |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.26 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-552-3 |
| MDL | MFCD00016936 |
| SMILES | O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13 |
| InChIKey | DANYIYRPLHHOCZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3 |
| PubChem CID | 5280442 |
| Target Point | Others |
| Passage | Others |
| Background | Acacetin is a class of flavonoids with a variety of important physiological activities, including antioxidant, anti-inflammatory and anti-cancer activities. |
| Biological Activity | Acacetin (5，7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1-2]. |
| Data Literature Source | [1]. Hong-Wei Zhang，et al. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Sci Rep. 2018 Jul 26;8(1):11255. [2]. Sang Keun Ha，et al. Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in vitro and in vivo. Neurochem Res. 2012 Jul;37(7):1560-7. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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