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beta-Lapachone

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Cat.No：IL0650 Solarbio

CAS：4707-32-8

Molecular Formula：C₁₅H₁₄O₃

Molecular Weight：242.27

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Reddish brown Solid

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Product Information

CAS	4707-32-8
Name	beta-Lapachone
Molecular Formula	C₁₅H₁₄O₃
Molecular Weight	242.27
Solubility	Soluble in DMSO/Ethanol
Purity	HPLC≥98%
Appearance	Reddish brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD01712233
SMILES	O=C(C1=C2OC(C)(C)CC1)C(C3=C2C=CC=C3)=O
InChIKey	QZPQTZZNNJUOLS-UHFFFAOYSA-N
InChI	InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
PubChem CID	3885
Target Point	Topoisomerase
Passage	DNA Damage/DNA Repair
Background	β-Lapachone is a naphthoquinone compound that is a topoisomerase I (topoisomerase I) inhibitor.
Biological Activity	β-Lapachone 是一种天然的萘醌类化合物，是拓扑异构酶 I (topoisomerase I) 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。[1-3]
Data Literature Source	[1]. Li CJ，et al. beta-Lapachone，a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993 Oct 25;268(30):22463-8. [2]. Vanni A，et al. DNA damage and cytotoxicity induced by beta-lapachone: relation to poly(ADP-ribose) polymerase inhibition. Mutat Res. 1998 Jun 5;401(1-2):55-63. [3]. Kim TW，et al. β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68(1):27-31.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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