Hydrocoumarin
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Cat.No：IH0410 Solarbio
CAS：119-84-6
Molecular Formula：C9H8O2
Molecular Weight：148.16
Storage：Store at 2-8℃，2 years
Purity：HPLC≥98%
Appearance：Liquid
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Hydrocoumarin
Product Information
| CAS | 119-84-6 |
| Name | Hydrocoumarin |
| Molecular Formula | C9H8O2 |
| Molecular Weight | 148.16 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Liquid |
| Storage | Store at 2-8℃，2 years |
| Density | 1.169g/mL |
| EC | EINECS 204-354-9 |
| MDL | MFCD00006881 |
| SMILES | O=C1CCC2=CC=CC=C2O1 |
| InChIKey | VMUXSMXIQBNMGZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2 |
| PubChem CID | 660 |
| Target Point | Sirtuin |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | Dihydrocoumarin is a yeast Sir2p inhibitor. |
| Biological Activity | Dihydrocoumarin 是在 Melilotus officinalis 中发现的一种化合物。Dihydrocoumarin 是酵母 Sir2p 抑制剂。 Dihydrocoumarin 还抑制人 SIRT1 和 SIRT2, IC 50 分别为 208 μM 和 295 μM[1]。 |
| IC50 | hSIRT1:208μM (IC50) [1]hSIRT2:295μM (IC50) [1] |
| Data Literature Source | [1]. Olaharski AJ， et al. The flavoring agent Dihydrocoumarin reverses epigenetic silencing and inhibits sirtuindeacetylases. PLoS Genet. 2005 Dec; 1 (6) :e77 |
| Unit | Bottle |
| Specification | 20mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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