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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > 4-Hydroxy-3,5-dimethoxycinnamic acidCAS：530-59-6
Molecular Formula：C11H12O5
Molecular Weight：224.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 530-59-6 |
| Name | 4-Hydroxy-3,5-dimethoxycinnamic acid |
| Molecular Formula | C11H12O5 |
| Molecular Weight | 224.21 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-487-3 |
| MDL | MFCD00004401 |
| SMILES | COC1=C(O)C(OC)=CC(/C=C/C(O)=O)=C1 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | It is a phenolic compound in the root of Hydnophytum formicarum Jack., an inhibitor of HDAC. |
| Biological Activity | Sinapinic acid (Sinapic acid) 是从 Hydnophytum formicarum Jack. 根中分离到的酚类化合物，为 HDAC 的抑制剂，IC50 值 2.27 mM[1]，对 ACE-I 的活性也有抑制作用[2]。Sinapinic acid 具有有效的抗肿瘤活性，诱导肿瘤细胞凋亡[1]。Sinapinic acid 具有抗氧化、抗糖尿病的作用[2]。Sinapinic acid 可以降低卵巢切除大鼠的总胆固醇、甘油三酯和 HOMA-IR 指数，并使抗氧化能力和氧化损伤的一些血清参数正常化[3]。 |
| Data Literature Source | [1]. Senawong T，et al. Histone deacetylase (HDAC) inhibitory and antiproliferative activities of phenolic-rich extracts derived from the rhizome of Hydnophytum formicarum Jack.: sinapinic acid acts as HDAC inhibitor. BMC Complement Altern Med. 2013 Sep 22;13:232. [2]. Quinn L，et al. Extraction and Quantification of Sinapinic Acid from Irish Rapeseed Meal and Assessment of Angiotensin-I Converting Enzyme (ACE-I) Inhibitory Activity. J Agric Food Chem. 2017 Aug 16;65(32):6886-6892. [3]. Zych M，et al. The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats. Oxid Med Cell Longev. 2018 Jun 4;2018:9274246. |
| Unit | Bottle |
| Specification | 20mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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