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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > IsatinCAS：91-56-5
Molecular Formula：C8H5NO2
Molecular Weight：147.13
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Orange to red Solid
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| CAS | 91-56-5 |
| Name | Isatin |
| Molecular Formula | C8H5NO2 |
| Molecular Weight | 147.13 |
| Solubility | Soluble in DMSO/Ethanol |
| Purity | HPLC≥98% |
| Appearance | Orange to red Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 202-077-8 |
| MDL | MFCD00005718 |
| SMILES | O=C1NC2=C(C=CC=C2)C1=O |
| InChIKey | JXDYKVIHCLTXOP-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11) |
| PubChem CID | 7054 |
| Target Point | MAO(Monoamine Oxidase) |
| Passage | Neuronal Signaling |
| Background | It is a potent inhibitor of monoamine oxidase (MAO). |
| Biological Activity | Isatin (Indoline-2, 3-dione) 是单胺氧化酶 (MAO) 的有效抑制剂, IC50 为3 μM。 也与中枢苯二氮卓受体结合 (对抗氯硝西泮IC50=123 μM) [1]。 还充当心房钠尿肽刺激和一氧化氮刺激的鸟苷酸环化酶拮抗剂[2]。 对5-羟色胺系统有影响[3]。 |
| IC50 | IC50: 3μM (MAO B) [1] |
| Data Literature Source | [1]. Glover V， et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry， 51 (2) ， 656–659. [2]. Igosheva N， et al. Isatin， an endogenous monoamine oxidase inhibitor， triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug; 47 (3) :216-24. [3]. McIntyre IM， et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990; 79 (1-2) :35-40. |
| Unit | Bottle |
| Specification | 20mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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