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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > α-mangostinCAS：6147/11/1
Molecular Formula：C24H26O6
Molecular Weight：410.27
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 6147/11/1 |
| Name | α-mangostin |
| Molecular Formula | C24H26O6 |
| Molecular Weight | 410.27 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 448-420-7 |
| MDL | MFCD00135200 |
| SMILES | O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(OC)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O |
| Target Point | Reactive oxygen species (ROS);IDH1 |
| Passage | Immunology & Inflammation |
| Background | α-mangostin is an inhibitor of IDH1 mutant (IDH1-R132H). |
| Biological Activity | α-mangostin对IDH1-R132H表现出选择性抑制作用，但对IDH1没有作用。 α-mangostin竞争性抑制α-mangostin（α-KG）与IDH1-R132H的结合。[1-2] |
| Data Literature Source | [1]. Kim HJ，et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5625-31. [2]. Lee HN，et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Discovery of Multitarget Inhibitors against Insect Chitinolytic Enzymes via Machine Learning-Based Virtual Screening
Click to check >>Author：Yi Ding, Sizhe Chen, Huan Liu, Tian Liu, Qing Yang
IF：5.8950
Publish_to：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
PMID：37254716
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