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Nuciferine

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Cat.No：IN0470 Solarbio

CAS：475-83-2

Molecular Formula：C₁₉H₂₁NO₂

Molecular Weight：295.38

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	475-83-2
Name	Nuciferine
Molecular Formula	C₁₉H₂₁NO₂
Molecular Weight	295.38
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD01664592
SMILES	CN1CCC2=CC(OC)=C(OC)C3=C2[C@@]1([H])CC4=CC=CC=C34
InChIKey	ORJVQPIHKOARKV-OAHLLOKOSA-N
InChI	InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1
PubChem CID	10146
Target Point	5-HT Receptor
Passage	Neuronal Signaling;GPCR & G Protein
Background	Nuciferine is a 5-HT2A, 5-HT2C and 5-HT2B antagonist.
Biological Activity	Nuciferine是DD2受体的部分激动剂，抑制多巴胺诱导的Gi激活。Nuciferine 是一种 5-HT2A，5-HT2C 和 5-HT2B 拮抗剂；也是 5-HT7 的反向激动剂，。Nuciferine可作为成虫蠕动的有效抑制剂[1-2]。
IC50	131nM(5-HT2C receptor)，150nM(5-HT7 receptor)，[1];EC50: 64nM(D2 receptor)， 700nM(5-HT6 receptor)[1]
Data Literature Source	[1]. Farrell MS，et al. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One. 2016 Mar 10;11(3):e0150602. [2]. Chan JD，et al. Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):364-370.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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