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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > PuerarinCAS：3681-99-0
Molecular Formula：C21H20O9
Molecular Weight：416.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 3681-99-0 |
| Name | Puerarin |
| Molecular Formula | C21H20O9 |
| Molecular Weight | 416.38 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 609-296-1 |
| MDL | MFCD00076007 |
| SMILES | O=C1C(C2=CC=C(O)C=C2)=COC3=C([C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)C(O)=CC=C13 |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | Puerarin is a 5-HT2C receptor antagonist. |
| Biological Activity | 葛根素是从葛根中提取的异黄酮，是5-HT2C受体拮抗剂。[1-4] |
| Data Literature Source | [1]. Hu W，et al. Puerarin inhibits iNOS，COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacol Rep. 2011;63(3):781-9. [2]. Zhang H，et al. Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). Mol Cell Biochem. 2011 Jun;352(1-2):117-23. [3]. Zhao L，et al. Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant，Anti-inflammatory，and Anti-apoptotic Mechanisms.J Agric Food Chem. 2016 Sep 28;64(38):7291-7. [4]. Pan X，et al. Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats. Med Sci Monit. 2015 Jul 23;21:2134-40. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Puerarin Alleviates H2O2-Induced Oxidative Stress and Blood–Milk Barrier Impairment in Dairy Cows
Click to check >>Author：Chenchen Lyu; Bao Yuan; Yu Meng; Shuai Cong; Haoyu
IF：6.2080
Publish_to：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：37175449
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