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Pristimerin

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Cat.No：IP0950 Solarbio

CAS：1258-84-0

Molecular Formula：C₃₀H₄₀O₄

Molecular Weight：464.64

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to yellow Solid

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Product Information

CAS	1258-84-0
Name	Pristimerin
Molecular Formula	C₃₀H₄₀O₄
Molecular Weight	464.64
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD01711331
SMILES	C[C@](C1=CC=C(C(C)=C2O)C3=CC2=O)(CC[C@]4(C)[C@@]5([H])C[C@@](C(OC)=O)(C)CC4)[C@]5(CC[C@]13C)C
Target Point	Monoacylglycerol lipase (MGL)
Passage	Metabolic Enzyme&Protease
Background	Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor.
Biological Activity	Pristimerin降低VEGF诱导的VEGFR2自身磷酸化，并减弱VEGF诱导的VEGFR2介导的信号通路的激活。Pristimerin是高效可逆的单酰基甘油脂肪酶(MGL)抑制剂，IC50值为93 nM。[1-2]
IC50	93nM(MGL)[1]
Data Literature Source	[1]. King AR，et al. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol. 2009 Oct 30;16(10):1045-52. [2]. Deng Q，et al. Pristimerin inhibits angiogenesis in adjuvant-induced arthritic rats by suppressing VEGFR2 signaling pathways. Int Immunopharmacol. 2015 Dec;29(2):302-13.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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