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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Propranolol HydrochlorideCAS：318-98-9
Molecular Formula：C16H21NO2·HCl
Molecular Weight：295.8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 318-98-9 |
| Name | Propranolol Hydrochloride |
| Molecular Formula | C16H21NO2·HCl |
| Molecular Weight | 295.8 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 206-268-7 |
| SMILES | OC(CNC(C)C)COC1=CC=CC2=CC=CC=C12.Cl |
| InChIKey | ZMRUPTIKESYGQW-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H |
| PubChem CID | 62882 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background | It is a nonselective β-adrenergic receptor (βAR) antagonist with high affinity for β1AR and β2AR. It is commonly used in related researches on controlling hypertension, pheochromocytoma, myocardial infarction, arrhythmia, angina pectoris and hypertrophic cardiomyopathy. |
| Biological Activity | Propranolol hydrochloride是一种非选择性β-肾上腺素能受体 (βAR) 拮抗剂, IC50 值为12 nM[1]。 |
| IC50 | IC50: 12nM (βAR) [1] |
| Data Literature Source | [1]. Briley M，et al. Evidence against beta-adrenoceptor blocking activity of diltiazem，a drug with calcium antagonistproperties. Br J Pharmacol. 1980 Aug; 69 (4) :669-73. [2]. Munabi NC，et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan; 5 (1) :45-55. [3]. Glennon RA，et al. The binding of propranolol at 5-hydroxytryptamine1D beta T355N mutant receptors may involve formation of two hydrogen bonds to asparagine. Mol Pharmacol. 1996 Jan; 49 (1) :198-206. [4]. Horinouchi T，et al. Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administrationof propranolol，atenolol and bevantolol. Life Sci. 2007 Jul 12; 81 (5) :399-404. Epub 2007 Jun 16 |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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