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Ruscogenin

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Cat.No：IR0230 Solarbio

CAS：472-11-7

Molecular Formula：C₂₇H₄₂O₄

Molecular Weight：430.62

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	472-11-7
Name	Ruscogenin
Molecular Formula	C₂₇H₄₂O₄
Molecular Weight	430.62
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 207-447-2
MDL	MFCD00210550
SMILES	C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])C[C@@]1([H])[C@@](CC=C(C[C@@H](O)C5)[C@@]6([C@@H]5O)C)([H])[C@]6([H])CC2
Target Point	NLRP3
Passage	Immunology & Inflammation
Background	Ruscogenin is an important steroidal sapogenin
Biological Activity	Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1-2].
Data Literature Source	[1]. Cao G，et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418. [2]. Huang YL，et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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