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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > Sinomenine HydrochlorideCAS：6080-33-7
Molecular Formula：C19H23NO4·HCl
Molecular Weight：365.85
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 6080-33-7 |
| Name | Sinomenine Hydrochloride |
| Molecular Formula | C19H23NO4·HCl |
| Molecular Weight | 365.85 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01714307 |
| SMILES | OC(C1=C2C[C@@]3([H])[C@](C=C4OC)([H])[C@@]1(CCN3C)CC4=O)=C(C=C2)OC.Cl |
| Target Point | NF-kB |
| Passage | NF-κB |
| Background | Sinomenine hydrochloride is a blocker of NF-κB activation and an activator of the μ-opioid receptor. |
| Biological Activity | Sinomenine hydrochloride 是 NF-κB 活化的阻断剂，也是 μ 阿片受体 (μ-opioid receptor) 的激活剂。[1-3] |
| Data Literature Source | [1]. Song L，et al. Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis. Biochem Biophys Res Commun. 2015 Aug 28;464(3):705-10. [2]. Gao T，et al. Analgesic effect of sinomenine in rodents after inflammation and nerve injury. Eur J Pharmacol. 2013 Dec 5;721(1-3):5-11. [3]. Zhu Q，et al. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Sci Rep. 2014 Dec 1;4:7270. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Sinomenine alleviates lipopolysaccharide-induced acute lung injury via a PPARβ/δ-dependent mechanism
Click to check >>Author：Li Zhao, Mengjie Zhang, Yang-Wuyue Liu, Yan Tan, Jun Yin, Yuanyuan Chen, Dewei Chen, Bing Ni
IF：5.0000
Publish_to：EUROPEAN JOURNAL OF PHARMACOLOGY
PMID：37307937
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