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Tanshinone ⅡA

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Cat.No：IT0530 Solarbio

CAS：568-72-9

Molecular Formula：C₁₉H₁₈O₃

Molecular Weight：294.34

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Orange to red Solid

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Product Information

CAS	568-72-9
Name	Tanshinone ⅡA
Molecular Formula	C₁₉H₁₈O₃
Molecular Weight	294.34
Solubility	Soluble in DMSO ≥4mg/mL(Need ultrasonic)
Purity	HPLC≥98%
Appearance	Orange to red Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00238692
SMILES	O=C(C1=C2C=CC3=C1CCCC3(C)C)C(C4=C2OC=C4C)=O
Target Point	VEGFR
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK
Background	It inhibits angiogenesis by targeting the protein kinase domain of VEGF/VEGFR2.
Biological Activity	Tanshinone IIA (Tan IIA) 是红根丹参根系中的主要脂溶性组合物之一。Tanshinone IIA 可以通过靶向 VEGF/VEGFR2 的蛋白激酶结构域来抑制血管生成。[1-3]
Data Literature Source	[1]. Xie J，et al. The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line. Acta Pharm Sin B. 2015 Nov;5(6):554-63. [2]. Zhang Z，et al. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. Am J Transl Res. 2016 Jul 15;8(7):3124-32. [3]. Su CC，et al. Tanshinone IIA decreases the protein expression of EGFR，and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016 Aug;36(2):1173-9.
Unit	Bottle
Specification	20mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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