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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > ER Stress > Tauroursodeoxycholic AcidCAS：14605-22-2
Molecular Formula：C26H45NO6S
Molecular Weight：499.7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 14605-22-2 |
| Name | Tauroursodeoxycholic Acid |
| Molecular Formula | C26H45NO6S |
| Molecular Weight | 499.7 |
| Solubility | Soluble in Water ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1308068-626-2 |
| MDL | MFCD00069496 |
| SMILES | C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| Target Point | ER Stress;ERK;Caspase;Apoptosis |
| Passage | ER Stress;MAPK; Apoptosis |
| Background | Tauroursodeoxycholate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate significantly reduces the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. |
| Biological Activity | Tauroursodeoxycholate 是一种内质网应激抑制剂。Tauroursodeoxycholate 显著降低凋亡分子如 caspase-3 和 caspase-12 表达。Tauroursodeoxycholate 也抑制 ERK。[1-2] |
| Data Literature Source | [1]. Kim SY，et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16. [2]. Qin Y，et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in Water 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism
Click to check >>Author：Yifan Shu, Yujie Huang, Wei Dong, Xia Fan, Yi Sun, Guijie Chen, Xiaoxiong Zeng, Hong Ye
IF：8.2000
Publish_to：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
PMID：37399869
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