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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Chloroquine DiphosphateCAS：50-63-5
Molecular Formula：C18H26ClN3·2H3PO4
Molecular Weight：515.86
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 50-63-5 |
| Name | Chloroquine Diphosphate |
| Molecular Formula | C18H26ClN3·2H3PO4 |
| Molecular Weight | 515.86 |
| Solubility | Soluble in Water ≥60mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-055-2 |
| MDL | MFCD00069852 |
| SMILES | O=P(O)(O)O.O=P(O)(O)O.CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN(CC)CC |
| InChIKey | QKICWELGRMTQCR-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4) |
| PubChem CID | 64927 |
| Target Point | Autophagy;ATM;Toll-like Receptor (TLR) |
| Passage | Autophagy;DNA Damage/DNA Repair; PI3K/Akt/mTOR;Immunology & Inflammation |
| Background | Chloroquine phosphate is an inhibitor of autophagy and Toll-like receptors (TLRs), as well as an ATM activator, and is widely used in researches such as antimalarial and anti-inflammatory drugs for the treatment of malaria and rheumatoid arthritis.According to reports, the drug can effectively inhibit the infection of the novel coronavirus 2019-nCoV that broke out in Wuhan at the cellular level. |
| Biological Activity | Chloroquine diphosphate是一种广泛用于治疗疟疾和类风湿性关节炎的抗疟疾和抗炎药。 Chloroquine 是 autophagy 和 toll-like receptors (TLRs) 的抑制剂。[1-3] |
| Data Literature Source | [1]. Said A，et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. [2]. Tuomela J，et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672. [3]. Mohamed FE，et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626. |
| Unit | Piece |
| Specification | 100mg 10mM*1mL in Water 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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