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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Fluoxetine HydrochlorideCAS：56296-78-7
Molecular Formula：C17H18F3NO·HCl
Molecular Weight：345.79
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 56296-78-7 |
| Name | Fluoxetine Hydrochloride |
| Molecular Formula | C17H18F3NO·HCl |
| Molecular Weight | 345.79 |
| Solubility | Soluble in Water ≥5mg/mL;Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 260-101-2 |
| MDL | MFCD00214288 |
| SMILES | FC(C1=CC=C(OC(C2=CC=CC=C2)CCNC)C=C1)(F)F.Cl |
| InChIKey | GIYXAJPCNFJEHY-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H |
| PubChem CID | 62857 |
| Target Point | 5-HT Receptor;Serotonin Transporter (SERT) |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is an effective selective serotonin reuptake inhibitor, which mainly inhibits the central nervous systems reabsorption of serotonin, and can be used in the treatment of depression, obsessive-compulsive disorder and bulimia nervosa. |
| Biological Activity | Fluoxetine hydrochloride是抗抑郁药和选择性的血清素重吸收抑制剂。[1-6] |
| Data Literature Source | [1]. Malberg JE，et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71 [2]. Kodama M，et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80. [3]. Wang JW，et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84. [4]. Bymaster FP，et al. Fluoxetine，but not other selective serotonin uptake inhibitors，increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61 [5]. Zhang W，et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. [6]. Su WJ，et al. Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance. J Neuroinflammation. 2017 Oct 30;14(1):210. |
| Unit | Piece |
| Specification | 50mg 10mM*1mL in DMSO 10mM*1mL in Water 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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