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Topotecan Hydrochloride

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Cat.No：IT1030 Solarbio

CAS：119413-54-6

Molecular Formula：C₂₃H₂₃N₃O₅·HCl

Molecular Weight：457.91

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	119413-54-6
Name	Topotecan Hydrochloride
Molecular Formula	C₂₃H₂₃N₃O₅·HCl
Molecular Weight	457.91
Solubility	Soluble in Water/DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 601-607-9
MDL	MFCD00866235
SMILES	[H]Cl.O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O
InChIKey	DGHHQBMTXTWTJV-BQAIUKQQSA-N
InChI	InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1
PubChem CID	60699
Target Point	Topoisomerase
Passage	DNA Damage/DNA Repair
Background	Topotecan Hydrochloride is a topoisomerase I inhibitor with anticancer activity.
Biological Activity	Topotecan Hydrochloride (SKF 104864A; NSC 609669) 是具有抗癌活性的拓扑异构酶I 抑制剂。[1-2]
Data Literature Source	[1]. Zhang FL，et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors，Shikonin and Topotecan，inhibit growth and induce apoptosis of glioma cells andglioma stem cells. [2]. Kumar S，et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17(17):5656-67.
Unit	Piece
Specification	10mg 10mM*1mL in DMSO 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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