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NSC23766

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Cat.No：IN0720 Solarbio

CAS：1177865-17-6

Molecular Formula：C₂₄H₃₅N₇·3HCl

Molecular Weight：530.96

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	1177865-17-6
Name	NSC23766 trihydrochloride
Molecular Formula	C₂₄H₃₅N₇·3HCl
Molecular Weight	530.96
Solubility	Soluble in Water/DMSO ≥1mg/mL
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD08703096
SMILES	NC1=CC(C)=NC2=CC=C(NC3=NC(NC(C)CCCN(CC)CC)=NC(C)=C3)C=C12.[H]Cl.[H]Cl.[H]Cl
Target Point	Rho;Rac GTPase
Passage	Cell Cycle
Background	NSC23766 is an inhibitor of Rac1 activation.
Biological Activity	NSC 23766 trihydrochloride 是 Rac1 激活的抑制剂[1-4]。
Data Literature Source	[1]. Veluthakal R，et al. NSC23766，a Known Inhibitor of Tiam1-Rac1 Signaling Module，Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39(2):760-7. [2]. Song SJ，et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3;6:34415 [3]. Zhao L，et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1，GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6;6:23972 [4]. Wang Y，et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar;173(5):937-50
Unit	Piece
Specification	5mg 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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