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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > NU 7026CAS：154447-35-5
Molecular Formula：C17H15NO3
Molecular Weight：281.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 154447-35-5 |
| Name | NU 7026 |
| Molecular Formula | C17H15NO3 |
| Molecular Weight | 281.31 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD06798345 |
| SMILES | O=C1C2=CC=C3C=CC=CC3=C2OC(N4CCOCC4)=C1 |
| Target Point | DNA-PK |
| Passage | DNA Damage/DNA Repair |
| Background | NU 7026 is a novel specific DNA-PK inhibitor. |
| Biological Activity | NU 7026 是一种新型特异性的 DNA-PK 抑制剂，IC50 为 0.23±0.01 μM，也抑制 PI3K，IC50 为 13±3 μM[1-3]。 |
| IC50 | DNA-PK:0.23μM;PI3K:13μM [1-3] |
| Data Literature Source | [1]. Veuger SJ，et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res. 2003 Sep 15;63(18):6008-15. [2]. Amrein L，et al. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J [3]. Nutley BP，et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer. 2005 Oct 31;93(9):1011-8. |
| Unit | Piece |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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