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Olaparib

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Cat.No：IO0330 Solarbio

CAS：763113-22-0

Molecular Formula：C₂₄H₂₃FN₄O₃

Molecular Weight：434.46

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	763113-22-0
Name	Olaparib
Molecular Formula	C₂₄H₂₃FN₄O₃
Molecular Weight	434.46
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 642-941-5
MDL	MFCD13185161
SMILES	O=C(C1=CC(CC(C2=C3C=CC=C2)=NNC3=O)=CC=C1F)N4CCN(C(C5CC5)=O)CC4
Target Point	PARP
Passage	Cell Cycle;DNA Damage/DNA Repair; Epigenetics
Background	Olaparib is a potent PARP inhibitor.
Biological Activity	Olaparib 是一种有效的 PARP 抑制剂，抑制 PARP-1 和 PARP-2 的 IC50 分别为 5 和 1 nM[1-4]。
IC50	PARP-2:1nM;PARP-1:5nM;tankyrase-1:1.5μM [1-4]
Data Literature Source	[1]. Menear KA，et al. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51(20):6581-91 [2]. Senra JM，et al. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Mol Cancer Ther. 2011 Oct;10(10):1949-58. [3]. Yasukawa M，et al. Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo. Int J Mol Sci. 2016 Feb 24;17(3):272. [4]. Bian X，et al. PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. Oncogene. 2018 Jan 18;37(3):341-351
Unit	Piece
Specification	5mg 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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