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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > 3POCAS：18550-98-6
Molecular Formula：C13H10N2O
Molecular Weight：210.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 18550-98-6 |
| Name | 3PO |
| Molecular Formula | C13H10N2O |
| Molecular Weight | 210.23 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00224002 |
| SMILES | O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2 |
| Target Point | PFKFB3 |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a small molecule inhibitor of PFKFB3. |
| Biological Activity | 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one)是PFKFB3的小分子抑制剂，对人源重组PFKFB3蛋白的IC50为22.9 μM，而且不抑制PFK-1活性。它能够抑制葡萄糖吸收、减少胞内Fru-2,6-BP, lactate, ATP, NAD+ 和 NADH的浓度。[1-2] |
| Data Literature Source | [1] Clem B，et al. Mol Cancer Ther. 2008，7(1):110-20. [2] Clem BF，et al. Mol Cancer Ther. 2013，12(8):1461-70. |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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