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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Pifithrin-α hydrobromideCAS：63208-82-2
Molecular Formula：C16H18N2OS·HBr
Molecular Weight：367.3
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 63208-82-2 |
| Name | Pifithrin-α hydrobromide |
| Molecular Formula | C16H18N2OS·HBr |
| Molecular Weight | 367.3 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00417851 |
| SMILES | N=C1SC2=C(CCCC2)N1CC(C3=CC=C(C)C=C3)=O.[H]Br |
| Target Point | p53;AhR |
| Passage | Apoptosis;Immunology & Inflammation |
| Background | Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents apoptosis. Pifithrin-α hydrobromide is also an agonist of aryl hydrocarbon receptor (AhR). |
| Biological Activity | Pifithrin-α hydrobromide是 p53 抑制剂，可阻断其转录活性并阻止细胞凋亡;也是 aryl hydrocarbon receptor (AhR) 的激动剂。(Pifithrin-α hydrobromide is a p53 inhibitor that blocks transcriptional activity and prevents cell apoptosis. It is also an agonist of aryl hydrocarbon receptor (AhR).) |
| Data Literature Source | [1]. Yu W，et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12(2):198-209. [2]. Hoagland MS，et al. The p53 Inhibitor Pifithrin-α Is a Potent Agonist of the Aryl Hydrocarbon Receptor. J Pharmacol Exp Ther. 2005 Aug;314(2):603-10. [3]. Kuang SQ，et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126(3):948-61. |
| Unit | Piece |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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