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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > PP2CAS：172889-27-9
Molecular Formula：C15H16ClN5
Molecular Weight：301.77
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 172889-27-9 |
| Name | PP2 |
| Molecular Formula | C15H16ClN5 |
| Molecular Weight | 301.77 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01568210 |
| SMILES | NC1=C2C(N(C(C)(C)C)N=C2C3=CC=C(Cl)C=C3)=NC=N1 |
| InChIKey | PBBRWFOVCUAONR-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19) |
| PubChem CID | 4878 |
| Target Point | Lck;Fyn |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | PP2 is a reversible, ATP-competitive Src family inhibitor. |
| Biological Activity | PP2 是可逆, ATP 竞争性的 Src 家族抑制剂, 抑制 Lck 和 Fyn的IC50 分别为 4 和 5 nM[1]。 |
| IC50 | IC50: 4nM (Lck) ， 5nM (Fyn) [1] |
| Data Literature Source | [1]. Hanke JH， et al. Discovery of a novel， potent， and Src family-selective tyrosine kinase inhibitor. Study of Lck-and FynT-dependentT cell activation. J Biol Chem. 1996 Jan 12; 271 (2) :695-701. [2]. Duxbury MS， et al. Inhibition of SRC tyrosine kinase impairs inherent and acquired Gemcitabine resistance in human pancreatic adenocarcinoma cells. Clin Cancer Res. 2004 Apr 1; 10 (7) :2307-18 [3]. Summy JM， et al. AP23846， a novel and highly potent Src family kinase inhibitor， reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol Cancer Ther. 2005 D [4]. Inoue A， et al. Phosphorylation of NMDA receptor GluN2B subunit at Tyr1472 is important for trigeminal processing of itch. Eur J Neurosci. 2016 Oct; 44 (7) :2474-2482. |
| Unit | Piece |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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