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R428

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Cat.No：IR0370 Solarbio

CAS：1037624-75-1

Molecular Formula：C₃₀H₃₄N₈

Molecular Weight：506.64

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	1037624-75-1
Name	R428
Molecular Formula	C₃₀H₃₄N₈
Molecular Weight	506.64
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD21608463
SMILES	NC1=NC(NC2=CC(CC[C@@H](N3CCCC3)CC4)=C4C=C2)=NN1C(N=N5)=CC6=C5C7=CC=CC=C7CCC6
Target Point	TAM Receptor
Passage	Protein Tyrosine Kinase/RTK
Background	It is a potent and selective Axl inhibitor.
Biological Activity	BGB324是一种高效的具有选择性的 Axl 抑制剂，IC50 值为 14 nM[1-3]。
IC50	14nM(Axl kinase)[1-3]
Data Literature Source	[1]. Sensi M，et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011 Dec;131(12):2448-57. [2]. Holland SJ，et al. R428，a selective small molecule inhibitor of Axl kinase，blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70(4):1544-54. [3]. Lijnen HR，et al. Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther. 2011 May;337(2):457-64
Unit	Piece
Specification	1mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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