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Ro-3306

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Cat.No：IR0390 Solarbio

CAS：872573-93-8

Molecular Formula：C₁₈H₁₃N₃OS₂

Molecular Weight：351.45

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥95%

Appearance：Yellow to brown Solid

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Product Information

CAS	872573-93-8
Name	Ro-3306
Molecular Formula	C₁₈H₁₃N₃OS₂
Molecular Weight	351.45
Solubility	Soluble in DMSO
Purity	HPLC≥95%
Appearance	Yellow to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD17392573
SMILES	O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC=C4N=CC=CC4=C3
Target Point	CDK;PKCδ;ERK;SGK
Passage	Cell Cycle
Background	Ro-3306 is a potent and selective CDK1 inhibitor.
Biological Activity	Ro-3306 是一种有效，选择性的 CDK1 抑制剂，对 CDK1，CDK1/cyclin B1 和 CDK2/cyclin E 的 Ki 值为分别为 20 nM，35 nM 和 340 nM。 RO-3306抑制p53诱导的p21合成。 RO-3306与Nutlin-3合作激活Bax并诱导线粒体凋亡。[1-3]
Data Literature Source	[1]. Vassilev LT，et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10660-5. [2]. Kojima K，et al. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 2009 Jun;100(6):1128-36. [3]. Jang WI，et al. A specific inhibitor of CDK1，RO-3306，reversibly arrests meiosis during in vitro maturation of porcine oocytes. Anim Reprod Sci. 2014 Jan 30;144(3-4):102-8
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Specification	5mg 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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